tecovirimat will improve the amount or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Watch for adverse effects if coadministered with sensitive substrates of these enzymes.ethinylestradiol will enhance the degree or impact of diazepam by System